CaRF A Neuronal Transcription Factor that CaREs
نویسندگان
چکیده
In this issue of Neuron, report the discovery of a new transcription factor, CaRF, that contributes to calcium stimulation of the BDNF gene through CaRE1, one of several calcium response elements found in the promoter of the BDNF gene. The CaRF/CaRE1 transcriptional pathway may control the expression of genes critical for activity-dependent, long-term changes in the central nervous system (CNS).
منابع مشابه
Genome-Wide Identification of Calcium-Response Factor (CaRF) Binding Sites Predicts a Role in Regulation of Neuronal Signaling Pathways
Calcium-Response Factor (CaRF) was first identified as a transcription factor based on its affinity for a neuronal-selective calcium-response element (CaRE1) in the gene encoding Brain-Derived Neurotrophic Factor (BDNF). However, because CaRF shares no homology with other transcription factors, its properties and gene targets have remained unknown. Here we show that the DNA binding domain of Ca...
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ورودعنوان ژورنال:
- Neuron
دوره 33 شماره
صفحات -
تاریخ انتشار 2002